袁晓燕 教授
Email: yuanxy@tju.edu.cn
研究所：先进高分子材料研究所
教育背景：
· 1993.9-1997.3，天津大学应用化学系,工学博士(在职)
· 1985.9-1988.3，天津大学材料系,高分子材料专业工学硕士
· 1981.9-1985.7，天津大学应用化学系,高分子化工专业工学学士
工作经历：
· 2003.7-今，天津大学，材料科学与工程学院，教授，博士生导师
· 2015.3-2015.9，美国Tufts大学，生物医学工程系，高级研究学者
· 1998.11-2001.4，香港理工大学，赛马会复康科技中心，副研究员
· 1997.7-2003.6，天津大学，材料科学与工程学院，副教授
· 1990.7-1997.6，天津大学，材料系，讲师
· 1988-3至1990.6，天津大学, 材料系, 助教
研究方向
· 研究领域：
生物医用材料：细胞冷冻保护剂、组织再生材料、电纺纤维膜、水凝胶
功能高分子材料：抗冻控冰材料、疏水防冰涂层
聚合物结构与性能：多组分高分子材料、嵌段共聚物结构表征
· 讲授课程：
《生物材料》本科生
《多组分高分子材料》研究生
承担项目
· 国家自然科学基金面上项目，糖功能化聚氨基酸的多级结构调控与冷冻保护细胞和蛋白质的研究，52373152，2024.01-2027.12，主持，在研
· 国家自然科学基金面上项目，生物杂化电纺纤维/水凝胶类血管基质材料及其自适应细胞诱导作用，52073204，2021.01-2024.12，主持，已结题
· 国家自然科学基金面上项目，海藻糖氨基酸共聚物的结构调控及其对红细胞的低温冻存保护作用，51773150，2018.01-2021-12，主持，已结题
· 天津市科委重点项目，氨基酸聚合物修饰的人工血管材料抗菌抗炎研究，17JCZDJC37500，2017.04-2020-03，主持，已结题
· 国家自然科学基金面上项目，多层聚丙交酯共聚物/壳聚糖电纺膜定位负载microRNA的血管再生活性材料，51473118，2015.01-2018-12，主持，已结题
· 国家自然科学基金面上项目， POSS-氟丙烯酸酯-聚硅氧烷共聚物微结构调控及低温防冰性能，51273146，2013.01-2016-12，主持，已结题
标志性成果：
1. Qingjing Niu, Ke Shang, Huimin Han, Binlin Chen, Kongying Zhu, Lixia Ren, Xiaoyan Yuan.Side-functionalization ofpoly(L-methionine) foricecontrol.Biomacromolecules, 2025, in press.https://doi.org/10.1021/acs.biomac.5c00086
2. Qing Wang, Liang Yuan, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Formation of electrospun membranes with high resilience byin situcrosslinking.Chem. Res. Chinese Universities, 2025, in press. https://doi.org/10.1007/s40242-025-5026-8
3. Liang Yuan, Yong Gao, Qing Wang, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Construction of small-diameter vascular grafts by electrospun zwitterionic diselenide-containing poly(ester urethane)urea with enhanced endothelialization.Acta Biomater.,2025, in press. https://doi.org/10.1016/j.actbio.2025.02.031
4. Binlin Chen, Yueqi Deng, Qingjing Niu, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. A close cognition of charged poly(L‑methionine) derivatives for antifreeze.Langmuir,2025, 41(2), 1260–1270.
5. 刘玉操,袁靓,尚轲,袁晓燕.基于硫辛酸的聚合物在生物医学中的应用. 离子交换与吸附, 2024, 40(06), 458–468.
6. Liang Yuan, Binlin Chen, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Development of macromolecular cryoprotectants for cryopreservation of cells.Macromol. Rapid. Comm.,2024, 45(19), 2400309.
7. Yueqi Deng, Binlin Chen, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Activation of upper critical solution temperature behaviors of zwitterionic poly(L-methionine-g-poly(sulfobetaine methacrylate)m) with a bottlebrush structure.Macromolecules,2024, 57(1), 191–200.
8. Yong Gao, Shan Bai, Kongying Zhu, Xiaoyan Yuan. Electrospun membranes of diselenide-containing poly(ester urethane)urea forin situ catalytic generation of nitric oxide. J. Biomat. Sci.-Polym. E.,2024, 35(8), 1157–1176.
9. Xiaogang Shi, Kongying Zhu, Xiaoyan Yuan. Improvement of mechanical properties of highly ZnO-filled polyethylene composites by dual-compatibilizer for hydrogen sulfide permeation inhibition.
Polym. Adv. Technol.,2024, 35(4), e6377.
10. Zongze Li, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Synthesis of trehalose-grafted poly(ester amide) with potential ice recrystallization inhibition activity.Polymer,2024, 296, 126819.
11. Qingjing Niu, Shuhui Gao, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Melittin enhanced intracellular trehalose with synergistic membrane stabilization of macromolecular protectants for cell cryopreservation. Sci. China Tech. Sci.,2024, 67(4), 1160–1169.
12. Shuhui Gao, Qingjing Niu, Yan Wang, Lixia Ren, Jinghui Chong, Kongying Zhu, Xiaoyan Yuan. A dynamic membrane-active glycopeptide for enhanced protection of human red blood cells against freeze-stress. Adv. Healthc. Mater., 2023, 12(10), 2202516.
13. Leilei Zang, Quhan Cheng, Shan Bai, Kai Wang, Xiaoyan Yuan. Electrospun membranes of carboxylated poly(ester urethane)urea/gelatin encapsulating pterostilbene for adaptive and antioxidative purposes.J. Biomat. Sci.-Polym. E.,2023, 34(9), 1171–1194.
14. Shan Bai, Jingai Zhang, Yong Gao, Xiaoqi Chen, Kai Wang, and Xiaoyan Yuan. Surface functionalization of electrospun scaffolds by QK-AG73 peptide for enhanced interaction with vascular endothelial cells.Langmuir,2023, 39(39), 14162–14172.
15. Shan Bai, Quhan Cheng, Leilei Zang, Kai Wang, Xiaoyan Yuan. Development of multifunctional peptidomimetic poly(ester urethane)urea scaffolds loading with chlorogenic acid. Mater. Today Commun.,2023, 35, 105981.
16. Yan Wang, Shuhui Gao, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Integration of trehalose lipids with dissociative trehalose enables cryopreservation of human RBCs.ACS Biomater. Sci. Eng.,2023, 9(1), 498–507.
17. 王清,白珊,袁晓燕.可降解弹性小口径人工血管材料的研究进展. 离子交换与吸附, 2023, 39(3), 203–215.
18. Zongze Li, Kongying Zhu, Lixia Ren, Xiaoyan Yuan. Sulfonium-containing glycopolypeptides tethering trehalose for protein stabilization.ACS Macro Lett.,2022, 11(11), 1278–1284.
19. Xingwen Liu, Shuhui Gao, Lixia Ren, Xiaoyan Yuan. Achieving high intracellular trehalose in hRBCs by reversible membrane perturbation of maltopyranosides with synergistic membrane protection of macromolecular protectants.Biomater. Adv.,2022, 141, 213114.
20. Qingjing Niu, Shuhui Gao, Kongying Zhu, Jinghui Chong, Lixia Ren, Xiaoyan Yuan. Membrane stabilization versus perturbation by aromatic monoamine-modified γ-PGA for cryopreservation of human RBCs with high intracellular trehalose.J. Mater. Chem. B,2022, 10(31), 6038–6048.
21. Shan Bai, Xiangyu Zhang, Leilei Zang, Lixia Ren, Xiaoyan Yuan. Development of L-arginine-based poly(ester urethane)urea for enhanced vascular adaptability. Sci. China Tech. Sci., 2022, 65(11), 2751-2762.
22. Shuhui Gao, Qingjing Niu, Xingwen Liu, Chenhui Zhu, Jinghui Chong, Lixia Ren, Kongying Zhu, Xiaoyan Yuan. Cryopreservation ofhuman erythrocytes through high intracellular trehalose with membrane stabilization of maltotriose-grafted ε-poly(L-lysine), J. Mater. Chem. B,2022, 10(23), 4452–4462.
23. Shuhui Gao, Kongying Zhu, Qifa Zhang, Qingjing Niu, Jinghui Chong, Lixia Ren, Xiaoyan Yuan. Development of icephilic ACTIVE glycopeptides for cryopreservation of human erythrocytes.Biomacromolecules,2022, 23(2), 530–542.
24. Xiangyu Zhang, Shan Bai, Leilei Zang, Xiaoqi Chen, Xiaoyan Yuan. Preparation of poly(ε-caprolactone)/poly(ester amide) electrospun membranes for vascular repair.Chem. Res. Chinese Universities,2022, 38(4), 1111–1117.
25. Xingwen Liu, Shuhui Gao, Qingjing Niu, Kongying Zhu, Lixia Ren, Xiaoyan Yuan.Facilitating trehalose entry into hRBCs at 4°C by alkylated ε-poly(L-lysine) for glycerol-free cryopreservation,J. Mater. Chem. B,2022, 10(7), 1042–1054.
26. Wenjing Song, Ke Guo, Zongze Li, Yunhui Zhao, Kongying Zhu, Xiaoyan Yuan. Enhancing mechanical properties of high-density polyethylene/polydopamine-modified basalt fiber composites via synergistic compatibilizers, Polym. Compos.,2022, 43(2), 1136–1146.
27. Shan Bai, Xiangyu Zhang, Leilei Zang, Songze Yang, Xiaoqi Chen, Xiaoyan Yuan. Electrospinning of biomaterials for vascular regeneration,Chem. Res. Chinese Universities, 2021, 37(3), 394–403.
28. Xuewei Zhao, Jie Peng, Shuhui Gao, Kongying Zhu, Yunhui Zhao, Xiaohui Li, Xiaoyan Yuan. Self-healing anti-icing coatings prepared from PDMS polyurea. Sci. China Tech. Sci., 2021, 64(7), 1535–1543.
29. Chixu Zhao, Xiaoyan Yuan, Shan Bai, Pingchuan Sun, YunHui Zhao, Kongying Zhu, Lixia Ren, Xiaohui Li. Antifogging and antibacterial properties of amphiphilic coatings based on zwitterionic copolymers,Sci. China Tech. Sci., 2021, 64(4), 817–826.
30. Qifa Zhang, Bo Liu, Jinghui Chong, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Combination of hydrophobically modified γ-poly(glutamic acid) and trehalose achieving high cryosurvival of RBCs.Sci. China Technol. Sc.,2021, 64(4), 806–816.
31. Meiling Wen, Hongyu Yan, Xin Shi, Yunhui Zhao, Kai Wang, Deling Kong, Xiaoyan Yuan. Modulation of vascular endothelial cells under shear stress on electrospun membranes containing REDV and microRNA-126. Int. J. Polym. Mater. Po.,2021, 70(15), 1090–1099.
32. 白景奇,白珊,任丽霞,朱孔营,赵蕴慧,李晓晖,袁晓燕. 海藻糖改性聚乙烯醇及其防雾/防霜涂层研究. 高等学校化学学报,2021,42 (8) 2683–2688.
33. Bo Liu, Lingyue Zhang, Qifa Zhang, Shuhui Gao, Yunhui Zhao, Lixia Ren, Wenxiong Shi, Xiaoyan Yuan. Membrane stabilization of poly(ethylene glycol)-b-polypeptide-g-trehalose assists cryopreservation of red blood cells.ACS Appl. Bio Mater.,2020, 3(5), 3294–3303.
34. Meiling Wen, Dengke Zhi, Lina Wang, Ce Cui, Ziqi Huang, Yunhui Zhao, Kai Wang, Deling Kong, Xiaoyan Yuan. Local delivery of dual microRNAs in trilayered electrospun grafts for vascular regeneration.ACS Appl. Mater. Interfaces,2020, 12(6), 6863–6875.
35. Shan Bai, Xiaohui Li, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan. Antifogging/antibacterial coatings constructed byN-hydroxyethylacrylamide and quaternary ammonium-containing copolymers.ACS Appl. Mater. Interfaces, 2020, 12(10), 12305–12316.
36. Jie Peng, Bo Liu, Shuhui Gao, Kongying Zhu, Yunhui Zhao, Xiaohui Li, Xiaoyan Yuan. Enhanced anti-icing properties of branched PDMS coatings with self-regulated surface patterns. Sci. China Technol. Sc.2020, 63(6), 960–970.
37. Bo Liu, Qifa Zhang, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan. Trehalose-functional glycopeptide enhances glycerol-free cryopreservation of red blood cells.J. Mater. Chem. B,2019, 7(37), 5695–5703.
38. Wenhong Hu, Zhenguang Li, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Endowing antibacterial ability to poly(ε-caprolactone) by blending with cationic-zwitterionic copolymers for biomedical purposes. Int. J. Polym. Mater. Po., 2019,
39. Bo Liu, Qifa Zhang, Fang Zhou, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Enhancing membrane-disruptive activity via hydrophobic phenylalanine and lysine tethered to poly(aspartic acid).ACS Appl. Mater. Interfaces,2019, 11(16), 14538–14547.
40. Meiling Wen, Fang Zhou, Ce Cui, Yunhui Zhao, Xiaoyan Yuan. Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs. Colloids Surf. B: Biointerfaces,2019, 182, 11036969.
41. Jipeng Han, Likun Xiong, Xingyu Jiang, Xiaoyan Yuan, Yong Zhao, Dayong Yang. Bio-functional electrospun nanomaterials: From topology design tobiological applications. Prog. Polym. Sci., 2019, 91, 1–28.
42. Shuhui Gao, Bo Liu, Jie Peng, Kongying Zhu, Yunhui Zhao, Xiaohui Li, Xiaoyan Yuan. Icephobic durability of branched PDMS slippage coatings co-cross-linked by functionalized POSS. ACS Appl. Mater. Interfaces,2019, 11 (4), 4654–4666.
43. Ce Cui, Meiling Wen, Fang Zhou, Yunhui Zhao, Xiaoyan Yuan. Target regulation of both VECs and VSMCs by dual-loading miRNA-126 and miRNA-145 in the bilayered electrospun membrane for small-diameter vascular regeneration.J. Biomed. Mater. Res. A,2019, 107A (2), 371–382.
44. Shan Bai, Xiaohui Li, Rongchun Zhang, Chuan Li, Kongying Zhu, Pingchuan Sun, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan. Enhancing antifogging/frost-resisting performances of amphiphilic coatings via cationic, zwitterionic or anionic polyelectrolytes. Chem. Eng. J., 2019, 357(1), 667–677.
45. Bo Liu, Tiantian Yao, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Antibacterial PCL electrospun membranes containing synthetic polypeptides for biomedical purposes.Colloids Surf. B: Biointerfaces,2018, 172, 330–337.
46. Chuan Li, Shan Bai, Xiaohui Li, Yunhui Zhao, Lixia Ren, Kongying Zhu, Xiaoyan Yuan. Amphiphilic copolymers containing POSS and SBMA withN-vinylcaprolactam andN-vinylpyrrolidone for THF hydrate inhibition.ACS Omega,2018, 3(7), 7371–7379.
47. Kongying Zhu#, Xiaohui Li#, Junfeng Su, Hui Li, Yunhui Zhao, Xiaoyan Yuan. Improvement of anti-icing properties of low surface energy coatings by introducing phase-change microcapsules. Polym. Eng. Sci.,2018, 58, 973-979.
48. Zhenguang Li, Wenhong Hu, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan. Integrated antibacterial and antifouling surfaces via cross-linking chitosan-g-eugenol/zwitterionic copolymer on electrospun membranes. Colloids Surf. B: Biointerfaces,2018, 169: 151–159.
49. Fang Zhou, Meiling Wen, Peiqiong Zhou, Yunhui Zhao, Xiaoling Jia, Yubo Fan, Xiaoyan Yuan. Electrospun membranes of PELCL/PCL-REDV loading with miRNA-126 for enhancement of vascular endothelial cell adhesion and proliferation. Mat. Sci. Eng. C-Mater.,2018, 85, 37–46.
50. Zhenguang Li, Peiqiong Zhou, Fang Zhou, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan. Antimicrobial eugenol-loaded electrospun membranes of poly(ε-caprolactone)/gelatin incorporated with REDV for vascular graft applications.Colloids Surf. B: Biointerfaces,2018, 162, 335–344.
51. Chao Tao, Shan Bai, Xiaohui Li, Chuan Li, Lixia Ren, Yunhui Zhao, Xiaoyan Yuan. Formation of zwitterionic coatings with an aqueous lubricating layer for antifogging/anti-icing applications.Prog. Org. Coat.,2018, 115, 56–64.