原续波教授
Email: xbyuan@tju.edu.cn
研究所：先进高分子材料研究所
入选教育部新世纪优秀人才
中国医师协会脑胶质瘤专委会基础研究与转化专委会委员
个人简历
教育背景：
· 1985.9 – 1989.7 北京理工大学化学工程系 工学学士
· 1992.9 – 1995.6 天津大学材料科学与工程系 工学硕士
· 1998.3 – 2001.6 天津大学材料科学与工程学院高分子系 工学博士
工作经历：
· 1989.7 – 1992.7 山西长治惠丰机械厂 助理工程师 副科长
· 1995.7 – 今 天津大学材料科学与工程学院讲师、副教授、教授
· 2002.9 – 2005.6 南开大学吸附与分离国家重点实验室，博士后
· 2010.1 – 2010.7 美国加州大学洛杉矶分校 访问学者
研究方向：
·研究领域：
纳米技术与药物投递系统，工程化外泌体，手术机器人及生物传感材料。
·讲授课程：
高分子材料科学基础，材料现代研究方法，高分子物理。
主持承担项目：
1. 国家重点研发计划，子课题负责人，2022～2025。
2.“治疗性抗体纳米微囊构建及靶向免疫治疗研究”, 国家自然科学基金，面上项目，2018～2021。
3.“靶向肿瘤微环境环境的功能蛋白、miRNA和阿霉素联合投递纳米微囊设计和肿瘤抑制研究”，国家自然科学基金，面上项目，2015～2018。
4.“超支化星形聚合物单分子胶束介导紫杉醇和as-miR-21共传递抑制恶性脑胶质瘤”，国家自然科学基金，面上项目，2011～2013。
5.“基因/药物同载时序性控制释放体系构建及肿瘤抑制研究”, 国家自然科学基金项目(合作),2012～2013
6.“功能纳米微粒介导基因治疗增效化疗”，教育部新世纪人才项目，2010～2012。
7.“载药超微粒表面多重生物功能因子组装介导药物跨血脑屏障靶向脑胶质瘤释放”，国家自然科学基金面上项目，2006～2008。
8.“可立体定位注射癌症缓释化疗制剂的产业化基础研究”，天津市科技攻关项目，2006～2009。
9.“可生物降解载药涂层冠状动脉支架研究”，校企横向合作项目 2006～2007。
10.“生物可降解PHB的化学合成关键问题研究”，天津市自然科学基金重点项目，2003～2005。
11.“载药超微粒表面生物功能化介导恶性脑胶质瘤靶向药物释放”，国家自然科学基金青年基金，2002～2004。
标志性成果
·主要学术成就、获奖及荣誉：
1. 2023年获北京市科技进步一等奖
2. 2013年获天津市教学成果一等奖
3.2009年获国家级教学成果二等奖
·发表文章、专著（代表作）：
1.Weijun Ji, Sidi Li, Xin Hou, Jin Zhao,Xubo Yuan. Multiple Non-Covalent Cross-Linked Multifunctional Strong Hemostatic Agent for Dynamic Exposure Hemostasis. Advanced Healthcare Materials, 2023: 2302574.IF=10.0,Top期刊
2.Changxin Hou, Huike Xing,Xubo Yuan*. Preparation and characterization of enzyme-responsive zwitterionic nanoparticles for monoclonal antibody delivery. Frontiers of Materials Science, 2023, 17(4): 1-12.
3. Sidi Li, Peng Sun, Wenguang Dou, Weijun Ji, Qingxi Wang, Xueping Li, Chan Liu, Jin Zhao, Hongliang Liu, Honglei Fan, Xin Hou,Xubo Yuan.Water-responsive entangled underwater adhesives enable strong adhesion in natural dynamic water.Chemical Engineering Journal, 2024, 479: 147639.IF=15.1,Top期刊
4.Xiaolei Sun, Xueping Li, Peng Tian, Jin Zhao, Hou Xin, Xinlong Ma*,Xubo Yuan*.The Sequential and Systemic Administration of BMP-2 and SDF-1α Nanocapsules for Promoting Osteoporotic Fracture Healing.Biomimetics, 2023, 8(4): 369.
5.Chaonan Zhang,Cheng Wei,Xingqi Huang,Changxin Hou,Chuan Liu,Shu Zhang,Zilong Zhao,Yafan Liu,Ruiguang Zhang,Lei Zhou,Ying Li,Xubo Yuan*,Jianning Zhang.*. MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury.BMC Medicine, 2023, 21, 199,IF=9.3,Top期刊
6.Xiaodong Zhu, Congcong Ma,Xubo Yuan*, Jin Zhao, Xin Hou. Synthesis of magnetic NaY zeolite for plasma proteomics application.Materials Today Communications, 2023, 35: 106219.
7.Xiaolei Sun, Aixian Tian, Peng Li, Jin Zhao, Xin Hou, Xinlong Ma*,Xubo Yuan*.SCIMP: A Novel Targeted Gene for Postmenopausal Osteoporosis Progression. Orthopaedic Surgery, 2023.
8.Weicheng Gao, Jie Chang, Xueping Li, Sidi Li, Yuwei Zhou, Xin Hou, Lixia Long, Jin Zhao,Xubo Yuan.A Quenched Double-Hydrophilic Coating for the Enhancement of Water Retention of Hydrogels.Advanced Functional Materials, 2023: 2303306.IF=19.0,Top期刊
9.Congcong Ma, Yanwei Li, Jie Li, Lei Song, Liangyu Chen, Na Zhao, Xueping Li, Ning Chen, Lixia Long, Jin Zhao, Xin Hou, Li Ren,Xubo Yuan.Comprehensive and deep profiling of the plasma proteome with protein corona on zeolite NaY.Journal of Pharmaceutical Analysis, 2023, 13(5): 503-513.IF=8.8,Top期刊
10.Lijie Li, Qi Zhan, Kaikai Yi, Ning Chen, Xueping Li, Shixue Yang, Xin Hou, Jin Zhao,Xubo Yuan*,Chunsheng Kang*.Engineering Lipusu with lysophosphatidylcholine for improved tumor cellular uptake and anticancer efficacy.Journal of Materials Chemistry B, 2022, 10(11): 1833-1842.
11.Sidi Li,Jiaqi Yu,Man Zhang,Zhenyu Ma,Ning Chen,Xueping Li,Jiamin Ban,Jiunan Xie,Zhennan Chen,Jiasheng Ma,Chunxi Tian,Yashuai Qin,Jian Wang,Weicheng Gao,Lixia Long,Jin Zhao,Xin Hou,Xubo Yuan.An Intermediate Unit-Mediated, Continuous Structural Inheritance Strategy for the Dilemma between Injectability and Robustness of Hydrogels.Advanced Functional Materials, 2022, 32, 2110617.IF=19.0,Top期刊
12.Zhang Man, Li Sidi,YuanXubo,Zhao Jin, Hou Xin. An in situ catechol functionalized epsilon-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis.International Journal of Biological Macromolecules, 2021, 191: 714-726.IF=8.2,Top期刊
13.Ning Chen, Sidi Li, Xueping Li, Qi Zhan, Lijie Li, Lixia Long, Jin Zhao*, Xin Hou*, Xubo Yuan*. Construction of enzymatic nanoreactors with high catalytic activity in millifluidic systems for cancer therapy. Chemical Engineering Journal, 2022, 429: 132305.IF=15.1,Top期刊
14.Xueping Li, Sidi Li, Hongzhao Qi, Donglin Han, Ning Chen, Qi Zhan, Zhaoyang Li, Jin Zhao, Xin Hou,XuboYuan,Xianjin Yang.Early healing of alveolar bone promoted by microRNA-21-loaded nanoparticles combined with Bio-Oss particles.Chemical Engineering Journal, 2020, 401: 126026.IF=15.1,Top期刊
15.Ning Chen,Sidi Li,Xueping Li,Lixia Long,Xubo Yuan,Xin Hou,Jin Zhao. Functionalization of PEG-PMPC-based polymers for potential theranostic applications. Frontiers of Materials Science, 2021, 15(2): 280-290.
16.Xiaomin Qian, Zhendong Shi, Hongzhao Qi, Ming Zhao, Kai Huang, Donglin Han, Junhu Zhou, Chaoyong Liu, Yang Liu, Yunfeng Lu,Xubo Yuan, Jin Zhao, Chunsheng Kang.A Novel Granzyme B Nanoparticle Delivery System Simulates Immune Cell Functions for Suppression of Solid Tumors.Theranostics, 2019, 9(25): 7616.IF=12.4,Top期刊
17.Jiamin Ban,Sidi Li,Qi Zhan,Xuepin Li,Huike Xing,Ning Chen,Lixia Long,Xin Hou,Jin Zhao,Xubo Yuan*. PMPC Modified PAMAM Dendrimer Enhances Brain Tumor-Targeted Drug Delivery.Macromolecular Bioscience, 2021, 21(4): 2000392.
18. Chaoyong Liu, Jing Wen, Dai Li, Hongzhao Qi, Lina Nih, Jialin Zhu, Duo Xu, Yu Ren, Shanshan Zhang, Donglin Han, Huanhuan Jia, Junhu Zhou, Meng Qin, Jialing Wu,Xubo Yuan, Ji Liu, Jin Zhao, Chunsheng Kang,Yunfeng Lu. Systemic delivery of microRNA for treatment of brain ischemia.Nano Research, 2021, 14(9): 3319-3328.IF=9.9,Top期刊
19. Qi Zhan, Kaikai Yi, Xiaoteng Cui, Xueping Li, Shixue Yang, Qixue Wang, Chuan Fang, Yanli Tan, Lijie Li, Can Xu,Xubo Yuan*, Chunsheng Kang*. Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy.Neuro-oncology, 2022, 24(11): 1871-1883.IF=15.9,Top期刊
20. Qi Zhan, Kaikai Yi, Xueping Li, Xiaoteng Cui, Eryan Yang, Ning Chen,Xubo Yuan, Jin Zhao, Xin Hou, Chunsheng Kang. Phosphatidylcholine-Engineered Exosomes for Enhanced Tumor Cell Uptake and Intracellular Antitumor Drug Delivery.Macromolecular Bioscience, 2021, 21(8): 2100042.
21. LiXia Long, LinJie Cheng, JingJing Hou, LiMei Wang, Xu Wang, LiGang He, SiDi Li, Jin Zhao, Xin Hou, ChunSheng Kang,XuBo Yuan*.The effect of umbrella-type branching on the blood circulation and tumor targeting of star-branched PLA-PMPC copolymer micelles.Science China Technological Sciences, 2021, 64: 71-82.
22. Weili Jin, Ye Wu, Ning Chen, Qixue Wang, Yunfei Wang, Yansheng Li, Sidi Li, Xing Han, Eryan Yang, Fei Tong, Jialing Wu,Xubo Yuan*, Chunsheng Kang. Early administration of MPC-n(IVIg) selectively accumulates in ischemic areas to protect inflammation-induced brain damage from ischemic stroke.Theranostics, 2021, 11(17): 8197.IF=12.4,Top期刊
23. Xiaolei Sun, Xueping Li, Hongzhao Qi, Xin Hou, Jin Zhao,Xubo Yuan*, Xinlong Ma*, MiR-21 Nanocapsules Promote Early Bone Repair of Osteoporotic Fractures by Stimulating the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells. Journal of Orthopaedic Translation,2020. IF=3.063
24. Qi Zhan, Kaikai Yi, Hongzhao Qi, Sidi Li, Xueping Li, Qixue Wang, Yunfei Wang, Chaoyong Liu, Mingzhe Qiu,Xubo Yuan, Jin Zhao, Xin Hou, Chunsheng Kang, Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy.Theranostics,2020,doi:10.7150/thno.45028.IF=8.063,Top期刊
25.Hongzhao Qi, Yin Wang,Xubo Yuan, Peifeng Li, Lijun Yang.Selective extracellular arginine deprivation by a single injection of cellular non-uptake arginine deiminase nanocapsules for sustained tumor inhibition.Nanoscale, 2020, 12(47): 24030-24043.
26. Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen,Xubo Yuan*, Yunfeng Lu*, Chunsheng Kang, Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Advanced Materials,2019,31(19): 1805697.IF=27.398,Top期刊
27. Sidi Li, Luyang Chen, Kai Huang, Ning Chen, Qi Zhan, Kaikai Yi, Hongzhao Qi, Chaoyong Liu, Yanli Tan, Xin Hou, Yunfeng Lu, Jin Zhao*,Xubo Yuan*, Chunsheng* Kang, Tumor Microenvironment-Tailored Weakly Cell-Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function, Advanced Functional Materials,2019, 29(43):1903296.IF=19.0, Top期刊
28. Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang, Sheng Xue, Jin Zhao, Xin Hou, Yin Wang, Peifeng Li,Xubo Yuan*, Hongzhao Qi*, Blood TfR+ Exosomes Separated by a pH-Responsive Method Deliver Chemotherapeutics for Tumor Therapy. Theranostics.2019, 9(25):7680-7696.IF=8.063, Top期刊
29. Hongzhao Qi, Lijun Yang, Xueping Li, Xiaolei Sun, Jin Zhao, Xin Hou , Zhaoyang Li*,Xubo Yuan*, Zhenduo Cui, Xianjin Yang, Systemic Administration of Enzyme-Responsive Growth Factor Nanocapsules for Promoting Bone Repair. Biomaterials Science,2019, 7, 1675-1685. IF= 6.183
专著：
《材料分析方法》，杜希文，原续波，天津大学出版社，2006. "十二五"普通高等教育本科国家级规划教材，普通高等教育"十一五"国家级规划教材，教育部普通高等教育精品教材。