赵瑾教授
Email: zhaojin@tju.edu.cn
研究所：先进高分子材料研究所
个人简历
教育背景：
· 1996.9 – 2000.6天津大学材料科学与工程系工学学士
· 2000.9 – 2003.6 天津大学材料科学与工程系 工学硕士
· 2003.9 – 2006.6 天津大学材料科学与工程系 工学博士
工作经历：
· 2006.7 –至今 天津大学材料科学与工程学院讲师、副教授、教授
研究方向
· 研究领域：
可注射水凝胶，生物粘合材料，仿生材料制造，骨组织工程材料
· 讲授课程：
材料现代研究方法-高分子部分（本科）
高分子基工程复合材料（本科）
生物医用高分子材料-部分（研究生）
主持承担项目：
1.“多物理场耦合调控多级有序结构功能体化学激光协同仿生制造”，国家重点研发计划，子课题负责人，2023～2026.
2.“动态力学环境响应性自增强可注射黏合水凝胶”，国家基金面上项目，负责人，2023～2026.
3.“医用手术机器人智能体模与风险仿真研究”，国家重点研发计划，子课题骨干，2022～2025.
4.“可注射microRNA活化水凝胶对炎症期巨噬细胞及干细胞的时序一体化调控及促骨修复研究”，国家基金面上项目，负责人，2017～2020.
5.“可注射microRNA活化凝胶掺杂骨粉促进植牙牙槽骨愈合的研究”，天津市面上项目，负责人，2017～2020.
6.“中药血清基组织粘附性可注射水凝胶的构建及其体内修复软骨研究”，国家基金合作项目，合作单位负责人，2016～2019.
7.“蛋白组学用蛋白捕获颗粒的开发”,企业横向项目，负责人，2021～2022.
8.“药物辅料产品性能检测及评价”，校企合作项目，负责人，2018～2019.
9.“多肽为交联剂的多糖-多肽原位凝胶及其用于周围神经吻合的应用基础研究”，国家基金青年基金项目，负责人，2012～2014.
10.“骨修复材料”，天津市项目，2007～2009.
标志性成果
· 主要学术成就、获奖及荣誉：
2023年获北京市科技进步一等奖
· 发表文章、专著（代表作）：
1.Weicheng Gao, Jie Chang, Xueping Li, Sidi Li, Yuwei Zhou, Xin Hou, Lixia Long*,Jin Zhao*, Xubo Yuan. A Quenched Double-Hydrophilic Coating for the Enhancement of Water Retention of Hydrogels. Advanced Functional Materials, 2023: 2303306.IF=19.0,Top期刊
2. Congcong Ma, Yanwei Li, Jie Li , Lei Song, Liangyu Chen , Na Zhao, Xueping Li , Ning Chen , Lixia Long ,Jin Zhao*, Xin Hou , Li Ren* , Xubo Yuan. Comprehensive and deep profiling of the plasma proteome with protein corona on zeolite NaY. Journal of Pharmaceutical Analysis, 2023, 13(5): 503-513.IF=14.26,Top期刊
3. Weijun Ji, Sidi Li, Xin Hou,Jin Zhao*, Xubo Yuan. Multiple Non-Covalent Cross-Linked Multifunctional Strong Hemostatic Agent for Dynamic Exposure Hemostasis. Advanced Healthcare Materials, 2023: 2302574.IF=10.0, Top期刊
4.Yuwei Zhou, Meiru Li, Weicheng Gao, Xueping Li, Lixia Long, Xin Hou,Jin Zhao*, Sidi Li, Xubo Yuan. Microstructure-united heterogeneous sodium alginate doped injectable hydrogel for stable hemostasis in dynamic mechanical environments. International Journal of Biological Macromolecules, 2023, 248: 125877.IF=8.2, Top期刊
5. Li Meiru, Zhou Yuwei, Li Xueping , Li Sidi,Zhao Jin*, Hou Xin, Yuan, Xubo，Highly stretchable, injectable hydrogels with cyclic endurance and shape-stability in dynamic mechanical environments, by microunit reformation. Journal of Materials Chemistry B, 2023, 11(13): 3001-3013. IF=7.571
6.Sidi Li, Jiaqi Yu, Man Zhang, Zhenyu Ma, Ning Chen, Xueping Li, Jiamin Ban, Jiunan Xie, Zhennan Chen, Jiasheng Ma, Chunxi Tian, Yashuai Qin, Jian Wang, Weicheng Gao, Lixia Long,Jin Zhao*, Xin Hou, Xubo Yuan. An Intermediate Unit-Mediated, Continuous Structural Inheritance Strategy for the Dilemma between Injectability and Robustness of Hydrogels. Advanced Functional Materials, 2022, 32(14): 2110617. IF=19.0,Top期刊
7. Lijie Li, Qi Zhan, Kaikai Yi, Ning Chen, Xueping Li, Shixue Yang, Xin Hou,Jin Zhao,* Xubo Yuan * and Chunsheng Kang. Engineering Lipusu with lysophosphatidylcholine for improved tumor cellular uptake and anticancer efficacy. Journal of Materials Chemistry B, 2022, 10(11): 1833-1842. IF=7.571
8. Jiaqi Yu, Xueping Li, Ning Chen, Suling Xue,Jin Zhao*, Sidi Li, Xin Hou, Xubo Yuan. Microgel-integrated, high-strength in-situ formed hydrogel enables timely emergency trauma treatment. Colloids and Surfaces B: Biointerfaces, 2022, 215: 112508.IF=5.999
9. Xueping Li, Suling Xue, Qi Zhan, Xiaolei Sun, Ning Chen, Sidi Li,Jin Zhao*, Xin Hou, and Xubo Yuan. Sequential Delivery of Different MicroRNA Nanocarriers Facilitates the M1-to-M2 Transition of Macrophages. ACS Omega, 2022, 10(11): 1833-1842. IF=4.132
10. Ning Chen, Sidi Li, Xueping Li, Qi Zhan, Lijie Li, Lixia Long,Jin Zhao*, Xin Hou, Xubo Yuan. Construction of enzymatic nanoreactors with high catalytic activity in millifluidic systems for cancer therapy. Chemical Engineering Journal, 2021, 429: 132305. IF=15.1,Top期刊
11. Chaoyong Liu, Jing Wen, Dai Li, Hongzhao Qi, Lina Nih, Jialin Zhu, Duo Xu, Yu Ren, Shanshan Zhang, Donglin Han, Huanhuan Jia, Junhu Zhou, Meng Qin, Jialing Wu, Xubo Yuan, Ji Liu,Jin Zhao*, Chunsheng Kang*, Yunfeng Lu*. Systemic delivery of microRNA for treatment of brain ischemia. Nano Research, 2021, 14(9): 3319-3328. IF=10.269, Top期刊
12. Qi Liu, Ning Chen, Xiangyun Yin, Lixia Long, Xin Hou*,Jin Zhao*, Xubo Yuan. Preparation of cellulose nanospheres via combining ZnCl2·3H2O pretreatment and p-toluenesulfonic hydrolysis as a two-step method. International Journal of Biological Macromolecules, 2021, 181:621-630.IF=8.2, Top期刊
13. Zhang Man, Li Sidi, Yuan Xubo,Zhao Jin*, Hou Xin*. An in situ catechol functionalized ε-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis. International Journal of Biological Macromolecule, 2021, 191:714-726. IF=8.2, Top期刊
14. Jiamin Ban, Sidi Li, Qi Zhan, Xuepin Li, Huike Xing, Ning Chen, Lixia Long, Xin Hou,Jin Zhao*, Xubo Yuan*. PMPC Modified PAMAM Dendrimer Enhances Brain Tumor-Targeted Drug Delivery. Macromolecular Bioscience, 2021, 21(4): 2000392. IF=5.825
15. Qi Zhan, Kaikai Yi, Xueping Li, Xiaoteng Cui, Eryan Yang, Ning Chen, Xubo Yuan,Jin Zhao*, Xin Hou*, Chunsheng Kang. Phosphatidylcholine-Engineered Exosomes for Enhanced Tumor Cell Uptake and Intracellular Antitumor Drug Delivery. Macromolecular Bioscience, 2021, 21(8): 2100042.IF=5.859
16. Suling Xue, Xueping Li, Sidi Li, Ning Chen, Qi Zhan, Lixia Long,Jin Zhao*, Xin Hou , Xubo Yuan. Bone fracture microenvironment responsive hydrogel for timing sequential release of cargoes. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, 629:127413.IF=5.518
17. Sidi Li, Ning Chen, Xueping Li, Yang Li, Zhipeng Xie, Zhenyu Ma, Jin Zhao*, Xin Hou, Xubo Yuan. Bioinspired Double-Dynamic-Bond Crosslinked Bioadhesive Enables Post-Wound Closure Care.Advanced Functional Materials, 2020: 2000130. IF=19.0,Top期刊
18. Xueping Li, Sidi Li, Hongzhao Qi, Donglin Han, Ning Chen, Qi Zhan, Zhaoyang Li,Jin Zhao*, Xin Hou, Xubo Yuan, Xianjin Yang. Early healing of alveolar bone promoted by microRNA-21-loaded nanoparticles combined with Bio-Oss particles. Chemical Engineering Journal, 2020, 401: 126026. IF=15.1,Top期刊
19. Sidi Li, Ning Chen, Yang Li, Xueping Li, Qi Zhan, Jiamin Ban,Jin Zhao*, Xin Hou*, Xubo Yuan*. Metal-Crosslinked ɛ-poly-L-lysine Tissue Adhesives with High Adhesive Performance: Inspiration from Mussel Adhesive Environment. International Journal of Biological Macromolecules,2020,153: 1251-1261.IF=8.2, Top期刊
20.Ying Du, Xin Hou*,Jin Zhao*, Xubo Yuan. Effect of neutralization on physicochemical/mechanical properties of hydroxypropylmethylcellulose acetate succinate. Materials Chemistry and Physics, 2020, 249: 122963. IF=4.778
21.Sidi Li, Luyang Chen, Kai Huang, Ning Chen, Qi Zhan, Kaikai Yi, Hongzhao Qi, Chaoyong Liu, Yanli Tan, Xin Hou, Yunfeng Lu,Jin Zhao*, Xubo Yuan*, Chunsheng Kang*. Tumor Microenvironment-Tailored Weakly Cell-Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function. Advanced Functional Materials,2019: 1903296. IF=19.0,Top期刊
专著：
Jin Zhao. “Chapter 6 -Chitosan Based Gels for Drug Delivery System” of the book “Chitosan-Based Hydrogels: Functions and Applications (Edited by Kangde Yao, et al)”, Taylor and Francis Group, CRC Press, 1 edition (July 28, 2011) (ISBN-13: 978-1439821145)