Yuan Xubo

Research direction

Synthesis of biodegradable polymers

Education

9/1998-6/2001 Ph. D., Department of Materials, Tianjin University 9/1992-6/1995 Masters Degree, Department of Materials Science and Technology, Tianjin University 9/1985-6/1989 Bachelors Degree, Department of Chemical Engineering, Beijing Institute of Technology;

Employment history

Professor, 2009-present, School of Materials Science and Engineering, Tianjin University; Associate professor, 2002-2009, School of Materials Science and Engineering, Tianjin University; Post-doctoral Appointment, Institute of Polymer Chemistry, Nankai University, Tianjin, China 2006; Assistant professor, 1997-2001, School of Materials Science and Engineering, Tianjin University; Lecturer, 1995-1997, School of Materials Science and Engineering, Tianjin University; Engineer, 1989-1992, Huifeng Co. Ltd., Shanxi province, China

Areas of research interest

- Synthesis of biodegradable polymers, Preparation of nanoparticles for drug delivery, Surface functionalization of nanoparticles and their interaction with the biomembranes, in vivo biodistribution and tumor-targeted drug delivery using nanoparticles, nanoparticle-mediated gene therapy in combination with chemotherapy for cancer research.

Teaching

Modern Research Methods of Materials; Frontier Development of Materials; Polymer Physics

Honors and awards

2009, National Second Prize for Teaching Achievements

Research projects

2011~2013, National Science Foundation of China, Iinhibition of malignant glioma by Hyperbranched star polymer single micelles mediated co-delivery of paclitaxel and as-miR-21
2010-2012, Project Foundation from New Century Excellent Talents Program, Functional nanoparticles mediated chemotherapeutic sensitization of gene therapy
2006~2008, National Science Foundation of China, Multi-biofunctional nonoparticles mediated biological of glioma-targeted drug release across blood-brain barrier
2006~2009, Key Project Foundation from Tianjin Science and Technology Research Program, Industrial Research of Stereotactic injection stained release chemotherapeutic agents in cancer therapy
2006~2007, Crosswise Cooperation Project between school and enterprise, Research on Biodegradable drug-coating coronary stent
2003~2005, Science Foundation of Tianjin, Key Research on Chemical Synthesis of Biodegradable PHB
2002~2004, National Science Youth Foundation of China, Surface Functional Modification and Drug Delivery Targeted Glioma of Nanoparticles

Selected publications(Journal articles, patents and books)

Wei-hua Ren, Jiang Chang, Cheng-hu Yan, Xiao-min Qian�ALi-xia Long, Bin He, Xu-bo Yuan, Chun-sheng Kang, Didier Betbeder, Jing Sheng, Pei-yu Pu, Development of transferrin functionalized poly(ethylene-glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma, J Mater Sci: Mater Med, 2010, 21:2673�V2681.

Yu Ren, Xuan Zhou, Mei Mei, Xu-bo Yuan*, Lei Han, Guang-Xiu Wang, Zhi-fan Jia, Peng Xu, Pei-yu Pu, Chun-sheng Kang*, MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to toxal, BMC Cancer, 2010,10:27.

ChunSheng Kang, XuBo Yuan*, Fei L,PeiYu Pu, Shizhu Yu,Guang-Xiu Wang, ChangHong Shen, Jin Chang. Evaluation of folate-PAMAM as an efficient carrier for antisense oligonucleotides delivery in rat C6 glioma cell: in vitro and in vivo. J Biomed Mater Res A. 2009, 93A: 585�V594.

Yu Ren, Chun-Sheng Kang*, Xu-bo Yuan*, Xuan Zhou, Peng Xu, Lei Han, Guang Xiu Wang, Zhifan Jia, Yue Zhong, Shizhu Yu, Jing Sheng, Pei-yu Pu .Co-delivery of As-miR-21 and 5-Fu by poly(amidoamine) dendrimer attenuate human glioma cell growth in vitro. J Biomater Sci Polym Ed ( DOI:10.1163/156856209X415828 ,in press).

Kang CS, Yuan XB*, Zhong Yue, Pu PY,Y Guo YS, Albadany A, Zhang ZY, Li YH, Chang J, Sheng J.Growth inhibition against intracranial C6 gliomas by stereotactic delivery of BCNU from controlled release poly(D,L-lactic acid) nanoparticles. Technol Cancer Res Treat.2009,8:61-70.

Xu-bo Yuan, Yan-bo Yuan, Wei Jiang, et al. Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 349(1-2): 241-248.

MQ Gu, XB Yuan*, CS Kang, YH Zhao, NJ Tian, PY Pu, J Sheng. Surface biofunctionalization of PLA nanoparticles through amphiphilic polysaccharide coating and gliand coupling: Evaluation of biofunctionalization and drug releasing behavior. Carbohyd Polym, 2007,67
417-426.

Wen-jie Ma, Xu-bo Yuan*, Chun-sheng Kang, et al, Evaluation of blood circulation of polysaccharide surface-decorated PLA nanoparticles, CARBOHYDRATE POLYMERS, 2008, 72(1):75-81.

Xu-bo Yuan, Hong Li, Yan-bo Yuan, Preparation of cholesterol-modified chitosan self-aggregated nanoparticles for delivery of drugs to ocular surface, Carbohydrate Polymer, 2006, 65(3):337-345.

Xu-Bo Yuan, Hong Li, Xiao-Xia Zhu, Hee-Gweon Woo, Self-aggregated nanoparticles composed of periodate-oxidized dextran and cholic acid: preparation, stabilization and in-vitro drug release, Journal of Chemical Technology & Biotechnology, 2006, 81(5):746�V754.

Yan, Cheng-hu, Yuan, Xu-bo, Kang, Chunsheng, Zhao, Yun-Hei, Liu, Jie, Guo, Yanshuang, Lu, Jian, Pu, Peiyu, Sheng, Jing, Preparation of carmustine-loaded PLA ultrasmall-nanoparticles by adjusting micellar behavior of surfactants, Journal of Applied Polymer Science, 110(4), pp 2446-2452.

Xu-bo Yuan, Chun-sheng Kang, Yun-hui Zhao, Ming-qi Gu, Pei-yu Pu, Neng-jiang Tian and Jing Sheng, Surface Multi-Functionalization of Poly(lactic acid) Nanoparticles and C6 Glioma Cell Targeting IN VIVO, Chinese Journal of Polymer Science, 2009, 27(2):1-9.

Social Appointments

Vice secretary general of National Association of Materials Experimental Teaching Research